[學(xué)位/學(xué)歷]
醫(yī)學(xué)博士 ?（四川大學(xué)華西口腔醫(yī)學(xué)院 ?口腔基礎(chǔ)醫(yī)學(xué) ?碩博連讀）
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[學(xué)術(shù)簡歷]
2010—2011年 ?美國伊利諾伊大學(xué)牙學(xué)院,，訪問學(xué)者
2014—2016年 ?中山大學(xué)光華口腔醫(yī)學(xué)院，博士后
2017年—至今 ?中山大學(xué)光華口腔醫(yī)學(xué)院,，助理研究員,，碩士生導(dǎo)師
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[研究方向]
1. 表觀遺傳調(diào)控在口腔腫瘤發(fā)生發(fā)展過程中的作用與機(jī)制
2. 代謝重編程對口腔腫瘤發(fā)生發(fā)展的影響及其機(jī)制
3. 單核苷酸多態(tài)性（SNP）對口腔腫瘤易感性的影響及其機(jī)制
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[主持課題]
1. 國家自然科學(xué)基金青年項(xiàng)目， ?LncRNA-p15135-miR-378a信號軸調(diào)節(jié)口腔鱗癌糖酵解的功能與機(jī)制研究,，2016.1-2018.12,，21.6萬元
2. 廣州市科技計(jì)劃項(xiàng)目，LncRNA-p4713通過Jak-STAT3通路調(diào)節(jié)口腔鱗癌惡性轉(zhuǎn)化的功能與機(jī)制，2018.4-2020.3,，20萬元
3. 中國博士后科學(xué)基金特別資助,，LncRNA-p23154介導(dǎo)FUT8甲基化在口腔癌中的作用機(jī)制,，2016.7-2016.11,，15 萬
4. 中國博士后科學(xué)基金面上項(xiàng)目一等資助，LncRNA-p23154調(diào)節(jié)口腔鱗癌糖酵解的功能與機(jī)制研究,，2015.5-2016.11，8 萬元
5. 中山大學(xué)青年教師培育項(xiàng)目,，LncRNA-p15135介導(dǎo)m6A結(jié)合蛋白HNRNPA2B1調(diào)控UHRF1在口腔癌中的機(jī)制研究,，2018.1-2020.12，15萬元
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[發(fā)表論文]
1. LncRNA-p23154 ?promotes the invasion-metastasis potential of oral squamous cell carcinoma by ?regulating Glut1-mediated glycolysis Cancer ?Letters. 2018 Oct 10;434:172-183.
2. Long ?non-coding RNA P4713 contributes to the malignant phenotypes of oral squamous ?cell carcinoma by activating the JAK/STAT3 pathway International Journal of ?Clinical and Experimental Pathology. 2017 10(11): 10947-10958
3. Integrative approach ?detected association between genetic variants of microRNA binding sites of ?TLRs pathway genes and OSCC susceptibility in Chinese Han Population.PloS ?One. 2014 ?Jul 7;9(7):e101695.
4. Genetic variants in the AKT1 gene are associated with ?risk of oral cancer: a Case-control study of the Chinese Han Population.J ?OralPathol Med. 2015 Jan;44(1):45-50.
5. Polymorphisms of ?microRNA-Binding Sites in Integrin Genes Are Associated with Oral Squamous ?Cell Carcinoma Susceptibility and Progression.The ?Tohoku Journal of Experimental Medicine. 2014 May;233(1):33-41.
6. Host ?genetic susceptibility to oral cancer: evidence from meta-analyses and pooled ?analyses. Oral ?Dis. 2014 Oct;20(7):644-9.
7. The association between hypoxia-inducible factor-1 α ?gene G1790A polymorphism and cancer risk: a meta-analysis of 28 case–control studies.Cancer ?Cell International. 2014, ?14:37 doi:10.1186/1475-2867-14-37
8. Prognostic significance of tumor infiltrating immune ?cells in oral squamous cell carcinoma.BMC cancer. 2017; 17: 375.
9. Foxp3 overexpression in tumor cells predicts poor ?survival in oral squamous cell carcinoma.BMC cancer. 2016 Jul 26; 16:530.
10. Overexpression of proteasonmal activator ?PA28αserves as a prognostic factor in oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016 Feb 19; 35:35
11. Associations between proteasomal activator ?PA28γ and outcome of oral squamous cell carcinoma: Evidence from cohort studies and functional analyses.EBioMedicine. 2015 Jul 10; 2(8):851-8.
12. Receptor for Activated C Kinase1 (RACK1): ?a regulator for migration and invasion in oral squamous cell carcinoma cells. J Cancer Res Clin Oncol. 2012 Apr; 138(4):563-71. 2011 Dec 30.
13. MicroRNA-138 suppresses ?epithelial-mesenchymal transition in squamous cell carcinoma cell lind. Biochem J. 2011 Nov 15; 440(1):23-31.
14. p53 regulates the expression of human ?angiotensin II AT(2) receptor interacting protein (ATIP1) gene. Oncol Lett. 2011 Sep; 2(5): 919-922.10.
15. Biodegradablethermosensitive ?hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma. PLoS One. 2012;7(4): e33860.
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[獲獎及學(xué)術(shù)榮譽(yù)]
1. ?2016 ? 中華口腔醫(yī)學(xué)會第五屆口腔生物醫(yī)學(xué)優(yōu)秀青年研究獎
2. ?2017 ? IADR中國分會第十三屆杰出青年學(xué)者獎
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[聯(lián)系方式]
地 ?址：廣州市陵園西路56號中山大學(xué)光華口腔醫(yī)學(xué)院·附屬口腔醫(yī)院（510055）
電 ?話：020-87330592
傳 ?真：020-87330592
E-mail：[email protected]
