[學(xué)位/學(xué)歷]
2005-2010 ?中山大學(xué)光華口腔醫(yī)學(xué)院?本科
2010-2012 ?中山大學(xué)光華口腔醫(yī)學(xué)院?七年制碩士?（口腔種植學(xué)）
2012-2015 ?澳大利亞昆士蘭科技大學(xué)?博士
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[學(xué)術(shù)簡(jiǎn)歷]
就職于中山大學(xué)光華口腔醫(yī)學(xué)院?附屬口腔醫(yī)院,，任研究員,、主治醫(yī)師（口腔種植科），博士生導(dǎo)師。現(xiàn)任中山大學(xué)科學(xué)研究院基地處副處長(zhǎng)，廣東省牙頜系統(tǒng)修復(fù)重建技術(shù)與材料工程技術(shù)研究中心副主任。入選國(guó)家海外高層次人才計(jì)劃,、廣東省杰出青年科學(xué)基金項(xiàng)目、廣東省珠江人才計(jì)劃青年拔尖人才項(xiàng)目,。
2012年畢業(yè)于中山大學(xué)光華口腔醫(yī)學(xué)院,，獲口腔臨床醫(yī)學(xué)（種植學(xué)）碩士學(xué)位。2015年畢業(yè)于澳大利亞昆士蘭科技大學(xué),，取得博士學(xué)位,。從事口腔種植相關(guān)醫(yī)教研工作，聚焦軟硬組織再生修復(fù)的免疫機(jī)制及其調(diào)控研究,，成果發(fā)表于Advanced Functional Materials,，ACS Nano，Materials Today等,。共發(fā)表SCI學(xué)術(shù)論文37篇,，累計(jì)影響因子達(dá)268.079，通訊10篇,，第一/并列第一16篇,，一作/通訊發(fā)表大于10分的SCI學(xué)術(shù)論文7篇。參編外語(yǔ)專著1部（The Immune Response to Implanted Materials and Devices）,。申請(qǐng)專利2項(xiàng),，參與獲批專利1項(xiàng)。主持包括ITI Research Grant, The Osteology Foundation Research Grant在內(nèi)的國(guó)際項(xiàng)目4項(xiàng),，國(guó)家自然科學(xué)基金在內(nèi)的項(xiàng)目5項(xiàng),。
? ??教學(xué)方面，參與口腔種植學(xué)的教學(xué)工作，并致力于推動(dòng)口腔基礎(chǔ)研究的教學(xué)改革與實(shí)踐,。主編《口腔基礎(chǔ)研究導(dǎo)論》（人民衛(wèi)生出版社，2020,，ISBN: 978-7-117-29325-9）,。從2016年起，作為學(xué)院“科創(chuàng)育才”協(xié)會(huì)指導(dǎo)教師與學(xué)生科聯(lián)合連續(xù)舉辦四屆“口腔科研訓(xùn)練營(yíng)”,，探索以第二課堂形式培養(yǎng)學(xué)生創(chuàng)新基礎(chǔ)研究能力,，并初步建立口腔創(chuàng)新基礎(chǔ)研究能力的教學(xué)評(píng)價(jià)體系；2020年作為課程負(fù)責(zé)人與教學(xué)科聯(lián)合創(chuàng)建“口腔基礎(chǔ)研究導(dǎo)論”課程,，將創(chuàng)新基礎(chǔ)研究能力的培養(yǎng)融入第一課堂,。從口腔基礎(chǔ)研究課程的建立與實(shí)踐、教材的編寫(xiě),、到教學(xué)評(píng)價(jià)體系的構(gòu)建,，這一系列的教學(xué)改革工作獲得了2項(xiàng)省級(jí)及3項(xiàng)校級(jí)教學(xué)類項(xiàng)目支持。
[研究方向]
1.?? ?口腔軟硬組織再生修復(fù)過(guò)程的免疫調(diào)控機(jī)制
2.?? ?口腔生物材料的免疫調(diào)控性能
3.?免疫智能口腔生物材料的研發(fā)及其在口腔軟硬組織再生修復(fù)中的應(yīng)用
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[主持課題]
教學(xué)類項(xiàng)目：
1.?? ?2020-2022年,，中山大學(xué)本科教學(xué)質(zhì)量工程類項(xiàng)目
2.?? ?2020-2021年,，廣東省高校青年教師高等教育學(xué)研究課題
3.?? ?2019-2019年，中山大學(xué)研究生教育創(chuàng)新計(jì)劃項(xiàng)目
4.?? ?2019-2020年,，廣東省高等教育教學(xué)研究和改革項(xiàng)目（綜合類項(xiàng)目,，第二參與人）
5.?? ?2018-2019年，中山大學(xué)本科教學(xué)質(zhì)量工程類項(xiàng)目
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科研類項(xiàng)目：
1.?? ?2018-2020年,，國(guó)家自然科學(xué)基金青年基金
2.?? ?2018-2021年,，廣東省杰出青年科學(xué)基金項(xiàng)目
3.?? ?2017-2022年，廣東省珠江人才計(jì)劃青年拔尖人才項(xiàng)目
4.?? ?2017-2019年,，中山大學(xué)青年教師培育項(xiàng)目
5.?? ?2016-2018年,，中山大學(xué)百人計(jì)劃啟動(dòng)基金
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國(guó)際項(xiàng)目：
1.?? ?2019-2020年，The ?Osteology Foundation, Young Researcher Grant (18-016)
2.?? ?2018-2020年,，ITI Research Grant,，Small Grant 2017 (1267_2017)
3.?? ?2016-2017年，The Osteology Foundation, Young ?Researcher Grant (15-004)
4.?? ?2015-2016年,，The Prince Charles Hospital Foundation,，New Investigator Gran t (NI2015-102)
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[發(fā)表論文（近三年）]
基礎(chǔ)研究：
1.?? ? ?Runheng ?Liu#, Shoucheng Chen#, Peina Huang, Guanqi Liu, Pu Luo, ?Zhipeng Li, Yin Xiao, Zhuofan Chen*,?Zetao ?Chen*. Immunomodulation-based strategy for improving soft tissue and ?metal implant integration and its implications in the development of metal ?soft tissue materials.. Advanced Functional Materials, 2020, accepted. (IF: ?15.621)
2.?? ? ?Guanqi ?Liu#, Xiaoshuang Wang#, Xuan Zhou#, Linjun ?Zhang, Jiaomei Mi, Zhengjie Shan, Baoxin Huang*, Zhuofan Chen*,?Zetao Chen*. Modulating the ?cobalt dose range to manipulate multisystem cooperation in bone environment: ?a strategy to resolve the controversies about cobalt use for orthopedic ?applications. Theranostics, 2020, 10(3), 1074-1089. (IF: 8.063)
3.?? ? ?Lingling ?Chen#, Guanqi Liu#, Jinyan Wu, Xuan Zhou, Yiming Zhao,?Zetao Chen*, Zhengmei Lin*, ?Yin Xiao. Multi-faceted effects of mesenchymal stem cells (MSCs) determined ?by immune microenvironment and their implications on MSC/biomaterial-based ?inflammatory disease therapy. Applied Materials Today, 2020, 18, 100458. (IF: ?8.013)
4.?? ? ?Zetao Chen#, ?Rahul Madathiparambil Visalakshan#, Jia Guo#, Fei Wei, ?Linjun Zhang, Lingling Chen, Zhengmei Lin*, Krasimir Vasilev*, Yin Xiao*. ?Plasma deposited poly-oxazoline nanotextured surfaces dictate ?osteoimmunomodulation towards ameliorative osteogenesis. Acta Biomaterialia, ?2019, 15: 568-581 (IF: 6.638)
5.?? ? ?Guanqi ?Liu#, Yuanlong Guo#, Linjun Zhang#, ?Xiaoshuang Wang, Runheng Liu, Peina Huang, Yin Xiao, Zhuofan Chen*,?Zetao Chen*. A standardized ?rat burr hole defect model to study maxillofacial bone regeneration. Acta Biomaterialia, ?2019, 86:456-60 (IF: 6.638)
6.?? ? ?Shiyu ?Wu#, Binbin Xia#, Sui Mai#, Zhicai Feng, ?Xiaoshuang Wang, Yudong Liu, Runheng Liu, Zhipeng Li, Yin Xiao*, Zhuofan ?Chen*,?Zetao Chen*. Sodium ?fluoride under dose range of 2.4-24 μM, a promising osteoimmunomodulatory ?agent for vascularized bone formation. ACS Biomaterials Science & ?Engineering, 2019, 5 (2): 817–830. (IF 4.511)
7.?? ? ?Wei ?Qiao#, Runheng Liu#, Zhipeng Li, Xin Luo, Baoxin Huang, ?Quan Liu,?Zetao Chen, James ?Kit Hon Tsoi, Richard Yu Xiong Su, Kenneth M.C. Cheung, Jukka Matinlinna*, ?Kelvin Yeung*, Zhuofan Chen*. Contribution of the in situ release of ?endogenous cations from xenograft bone driven by fluoride incorporation ?toward enhanced bone regeneration. Biomaterials Science, 2018, 6: 2951-64 (IF ?5.251)
8.?? ? ?Fei ?Wei#, Guanqi Liu#, Yuanlong Guo, Ross Crawford,?Zetao Chen*, Yin Xiao*. Blood ?prefabricated hydroxyapatite/tricalcium phosphate induces ectopic ?vascularized bone formation via modulating the osteoimmune environment. ?Biomaterials Science, 2018, 6(8):2156-71 (IF 5.251)
9.?? ? ?Runheng ?Liu#, Yixiong Lin#, Jinying Lin#, Linjun ?Zhang, Xueli Mao, Baoxin Huang, Yin Xiao, Zhuofan Chen*,?Zetao Chen*. Blood prefabrication subcutaneous small ?animal model for the evaluation of bone substitute materials. ACS ?Biomaterials Science & Engineering, 2018, 4(7):2516-2527 (IF ?4.511)
10.??Zetao Chen#, ?Lingling Chen#, Runheng Liu#, Yixiong Lin, Shoucheng ?Chen, Shifeier Lu, Zhengmei Lin, Zhuofan Chen*, Chengtie Wu*, Yin Xiao*. The osteoimmunomodulatory ?property of barrier collagen membrane and its manipulation via coating ?nanometer-sized bioactive glass to improve guided bone regeneration. ?Biomaterials Science, 2018, 6(5):1007-19 (IF 5.251)
11.??Runheng ?Liu#, Wei Qiao#, Baoxin Huang,?Zetao Chen, Jinghan Fang, Zhipeng Li*, Zhuofan Chen*, ?Fluorination enhances osteogenic capacity of porcine hydroxyapatite, Tissue ?Engineering Part A, 2018, 24(15-16):1207-17 (IF 3.616)
12.??Shoucheng ?Chen#, Yuanlong Guo#, Runheng Liu#, Shiyu ?Wu, Jinghan Fang，?Baoxin Huang, ?Zhipeng Li, Zhuofan Chen*,?Zetao ?Chen*. Tuning surface properties of bone biomaterials to manipulate ?osteoblastic cell adhesion and the signaling pathways for the enhancement of ?early osseointegration. Colloids and Surfaces B: Biointerfaces, 2018, 164: ?58-69. (IF: 3.973)
13.??Zetao Chen#, ?Shengwei Han#, Mengchao Shi, Guanqi Liu, Zhuofan Chen, Jiang ?Chang, Chengtie Wu*, Yin Xiao*. Immunomodulatory effects of mesoporous silica ?nanoparticles on osteogenesis: from nanoimmunotoxicity to nanoimmunotherapy. ?Applied Materials Today, 2018, 10: 184-93. (IF: 8.013)
14.??Zetao Chen#, Akash ?Bachhuka#, Fei Wei, Xiaoshuang Wang, Guanqi Liu, Krasimir Vasilev*, ?Yin Xiao*. Nanotopography-based strategy on the precise manipulation of ?osteoimmunomodulation in bone regeneration. Nanoscale, 2017, 9: 18129-52. (IF: ?6.970)
15.??Mengchao ?Shi#, Lunguo Xia#,?Zetao ?Chen, Fang Lv, Huiying Zhu, Fei Wei, Shengwei Han, Jiang Chang, Yin ?Xiao*, Chengtie Wu*. Europium-doped mesoporous silica nanosphere as an immune-modulating ?osteogenesis/angiogenesis agent. Biomaterials, 2017, 144: 176-87. (IF: ?10.273)
16.??Xufang ?Zhang#, Qingpiao Chen#, Jianwei Liu, Qi Wei,?Zetao Chen, Xueli Mao*. ?Parthenolide promotes differentiation of osteoblasts through Wnt/β-catenin ?signaling pathway in inflammatory environment. Journal of Interferon and ?Cytokine Research, 2017, 37(9): 406-414. (IF:1.774)
17.??Zetao Chen#, ?Akash Bachhuka#, Shengwei Han, Fei Wei, Shifeier Lu, Rahul ?Visalakshan, Krasimir Vasilev*, Yin Xiao*. Tuning chemistry and topography of ?nanoengineered surfaces to manipulate immune response for bone regeneration ?applications. ACS Nano, 2017, 11(5): 4494-506. (IF 13.903)
18.??Gaojie ?Yang#, Haoming Liu#, Xixi Hu,?Zetao Chen,?Thor Friis, Jianglin Wang, Yin Xiao*, Shengmin ?Zhang*. Bio-inspired hybrid nanoparticles promote vascularized bone ?regeneration in a morphology-dependent manner. Nanoscale, 2017, 9: 5794-805. ?(IF ?6.970)
19.??Shengwei ?Han,?Zetao Chen*, Pingping ?Han, Qingang Hu, Yin Xiao*. Activation of macrophages by lipopolysaccharide ?for assessing the immunomodulatory property of biomaterials. Tissue ?Engineering Part A, 2017, 23 (19-20): 1100-9. (IF 3.616)
20.??Zetao Chen#, ?Siyu Ni#, Shengwei Han, Ross Crawford, Shifeier Lu, Fei Wei, Jiang ?Chang, Chengtie Wu*, Yin Xiao*. Nanoporous microstructures mediate ?osteogenesis by modulating the osteo-immune response of macrophages. ?Nanoscale. 2017, 9: 706-18. (IF 6.970)
臨床研究：
21.??Yudong ?Liu#,Qifan Liu#, Zhipeng Li, Aneesha ?Acharya, Danying Chen,?Zetao Chen, ?Nikos Mattheos, Zhuofan Chen*, Baoxin Huang*. Long noncoding RNA and mRNA ?expression profiles in peri-implantitis versus periodontitis. Journal of ?periodontal research, 2019, accepted. (IF: 2.613)
22.??Rachana ?Shrestha#, Xin Liu#, Shoucheng Chen, Zhipeng Li,?Zetao Chen, Edmond H. N. Pow,，Zhuofan Chen*, ?Baoxin Huang*. Correlation of anterior overbite with root position and buccal ?bone thickness of maxillary anterior teeth: a CBCT study. Surgical and ?Radiologic Anatomy. 2019,41(8):935-942. (IF:1.039)
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[參編教材與論著]
1.?? ? ??主編《口腔基礎(chǔ)研究導(dǎo)論》,，人民衛(wèi)生出版社，2020,，ISBN: ?978-7-117-29325-9
2.?? ? ?參編英文專著'The Immune ?Response to Implanted Materials and Devices',?by ?editor Bruna Corradetti, Springer-Verlag, 2017. ISBN: 978-3-319-45431-3. Zetao ?Chen, Chengtie Wu, Yin Xiao. 'Convergence of osteoimmunology and ?immunomodulation for the development and assessment of bone biomaterials.'
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[獲獎(jiǎng)及學(xué)術(shù)榮譽(yù)]
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1.?? ??2019/2018中山大學(xué)光華口腔醫(yī)學(xué)院本科教學(xué)優(yōu)秀教師獎(jiǎng),，二等獎(jiǎng)
2.?? ??AIDE - Young Australia China Alumni ?of the Year Award of the ACAA and TOEFL? - 2018 Australia China ?Alumni Awards, finalist.
3.?? ??2017全國(guó)口腔生物醫(yī)學(xué)學(xué)術(shù)年會(huì)優(yōu)秀青年研究獎(jiǎng)三等獎(jiǎng)
4.?? ??2017年IADR中國(guó)分會(huì)杰出青年學(xué)者獎(jiǎng)比賽二等獎(jiǎng)
5.?? ??中華口腔醫(yī)學(xué)會(huì)科研管理專委會(huì)年會(huì)2017國(guó)際口腔醫(yī)學(xué)青年科學(xué)家論壇明日之星獎(jiǎng)
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[社會(huì)兼職]
1.?? ?廣東省青年聯(lián)合會(huì)第十一屆委員會(huì)委員
2.?? ?中華口腔醫(yī)學(xué)會(huì)第三屆口腔生物學(xué)專業(yè)委員會(huì)委員
3.?? ?廣東省口腔醫(yī)學(xué)會(huì)第三屆口腔種植學(xué)專委會(huì)委員
4.?? ??中國(guó)生物材料學(xué)會(huì)青年委員會(huì)第二屆委員會(huì)委員
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[聯(lián)系方式]
地?址：廣州市陵園西路56號(hào)中山大學(xué)光華口腔醫(yī)學(xué)院·附屬口腔醫(yī)院（510055）
電?話：020-87330592
傳?真：020-83822807
E-mail：[email protected]
