中山大學(xué)“百人計劃二期”引進(jìn)人才
[學(xué)位/學(xué)歷]
理學(xué)學(xué)士 (中國農(nóng)業(yè)大學(xué)生物學(xué)院,，生物科學(xué))
理學(xué)博士（中國農(nóng)業(yè)大學(xué)生物學(xué)院,，生理學(xué),，師從夏國良教授）
[學(xué)術(shù)簡歷]
2008-2011年,，博士后研究員,，美國路易斯安那州立大學(xué)健康科學(xué)中心 ?
2011-2016年,，資深博士后研究員,，美國斯托沃斯醫(yī)學(xué)研究所 ? ?
2016年12月起,，副研究員，博士生導(dǎo)師,，中山大學(xué)百人計劃引進(jìn)人才,。中山大學(xué)光華口腔醫(yī)學(xué)院?附屬口腔醫(yī)院,，中山大學(xué)口腔醫(yī)學(xué)研究所，廣東省口腔醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室
本人綜合運(yùn)用Ribosome profiling,、Droplet digital PCR和分子生物學(xué),、發(fā)育和細(xì)胞生物學(xué)、生物化學(xué)等一系列技術(shù)手段,，圍繞著人類口腔重要疾病的基礎(chǔ)醫(yī)學(xué)機(jī)制開展了一系列開拓性研究,，分別在口腔顱頜面遺傳性疾病和發(fā)育畸形的分子機(jī)制和治療靶點(diǎn)、核糖體DNA拷貝數(shù)變異決定口腔癌癥化療敏感性,、哺乳動物雷帕霉素靶蛋白mTOR信號通路在腫瘤治療中的作用機(jī)制等方面取得了顯著的成果,。相關(guān)工作發(fā)表在Proc Natl Acad Sci U S A、Cell Reports,、PLoS Genetics,、Human Molecular Genetics、Carcinogenesis,、Free Radical Biology and Medicine,、Laboratory Investigation等重要期刊上。根據(jù)科學(xué)引文索引（SCI-EXPANDED）數(shù)據(jù)庫的最新文獻(xiàn)檢索報告,，至今共發(fā)表SCI研究論文31篇（IF≥6分的論文7篇）,，論文影響因子總和為135.33分，累計他引次數(shù)589次,；其中申報人以第一（含并列）作者發(fā)表研究論文13篇（IF≥5分的論文5篇）,，累計影響因子52.093分，累計他引次數(shù)313次,，單篇第一作者論文他引次數(shù)最高90次,，H指數(shù)為17。由于本人在口腔疾病研究中獲得的突出成果,，至今在國際學(xué)術(shù)研討會上受邀進(jìn)行會議報告4次,。同時，申報人以獨(dú)立PI身份主持美國Cornelia de Lange Syndrome (CdLS) Foundation科研基金1項(xiàng),，以項(xiàng)目組第二完成人身份承擔(dān)美國Cornelia de Lange Syndrome (CdLS) Foundation和March of dimes (MOD) Foundation科研基金2項(xiàng),。
[研究方向]
1.顱頜面部組織發(fā)育畸形與缺損的修復(fù)和重建研究，主要圍繞口腔顱頜面部發(fā)育缺陷的遺傳基礎(chǔ),，以及顱頜面軟組織修復(fù)和再生的細(xì)胞和分子機(jī)制展開研究,。
2.腫瘤發(fā)生發(fā)展的蛋白翻譯調(diào)控機(jī)理研究，重點(diǎn)圍繞癌癥早期診斷,、腫瘤分化的分子分型,、新型生物標(biāo)志物的發(fā)現(xiàn),，以及重要信號蛋白和小分子代謝產(chǎn)物新功能的闡述和新藥靶分子的功能性驗(yàn)證。
[主持課題]
1.中山大學(xué)百人計劃科研啟動基金，2016/12-2021/12,，在研，主持,，120萬元,。
2.美國Cornelia de Lange綜合癥基金會科研基金項(xiàng)目“Targeting translation in Cornelia de Lange Syndrome human cells with L-leucine”，2014/9-2015/8,，已結(jié)題,，主持，3750美元,。
3.美國March of Dimes出生缺陷基金會發(fā)現(xiàn)和轉(zhuǎn)化醫(yī)學(xué)研究基金項(xiàng)目“L-leucine as a potential therapy for Cornelia de Lange Syndrome”,，2014/6-2017/5，已結(jié)題,，第二完成人,，235000美元。
4.美國Cornelia de Lange綜合癥基金會2013-2014年科研基金項(xiàng)目“Treatment of Zebrafish Models for CdLS with L-leucine”,，2013/9-2014/8,，已結(jié)題，第二完成人,，5000美元,。
5.國家自然科學(xué)基金面上項(xiàng)目“促減數(shù)分裂甾醇合成酶CYP51基因沉默對卵母細(xì)胞減數(shù)分裂恢復(fù)作用機(jī)理的研究”，2006/01-2008/12,，已結(jié)題,，第四完成人，28萬元,。
6.國家自然科學(xué)基金面上項(xiàng)目“心鈉肽在輸卵管中的分泌調(diào)節(jié)及其對受精的作用和機(jī)理”,，2007/01-2009-12，已結(jié)題,，第五完成人,，26萬元。
7.國家自然科學(xué)基金青年項(xiàng)目“利用RNA干擾技術(shù)治療小鼠高膽固醇血癥的研究”,，2008/01-2010/12,，已結(jié)題，第二完成人,，18萬元,。
[發(fā)表論文]
1.Baoshan Xu, Hua Li, John M. Perry, Vijay Pratap Singh, Jay Unruh, Zulin Yu, Musinu Zakari, William McDowell, Linheng Li, Jennifer L. Gerton*. ?Ribosomal DNA copy number can be lost in cancer. PLoS Genetics. 2017 Jun 22;13(6):e1006771. (IF: 6.661)（Highlighted feature in the Scientist Magazine）.
2. ?Baoshan Xu, Kenneth K. Lee, Lily Zhang, Jennifer L. Gerton*. ?Stimulation of mTORC1 with L-leucine Rescues Defects Associated with Roberts Syndrome. PLOS Genetics. 2013 Oct; 9(10):e1003857. (IF: 6.661) （Highlighted feature in the Science News Site Science Daily）.
3.Baoshan Xu, Nenja Sowa, Maria E. Cardenas, Jennifer L. Gerton*. ?L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. Human Molecular Genetics, 2015 Mar 15; 24 (6):1540-1555. (IF: 5.985)
4.Baoshan Xu, Karin Zueckert, Madelaine Gogol, and Jennifer L. Gerton*. ?L-leucine stimulation of mTORC1 partially rescues transcription and translation in Roberts Syndrome. BMC Genomics, 2016 Jan 5;17(1):25. (IF: 3.867)
5.Baoshan Xu#, Sujuan Chen#(Co-first author), Yan Luo, Zi Chen, Lei Liu, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Long Chen*, Shile Huang*. ?Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLOS ONE, 2011, April 22; 6(4) e19052. (IF: 3.057)
6.Baoshan Xu, Shuai Lu, Jennifer L. Gerton*. Roberts syndrome-a deficit in acetylated cohesin at heterochromatic regions leads to nucleolar dysfunction. Rare Diseases, 2014 Jan., e27743.
7.Baoshan Xu#, Chao Wang#(Co-first author),, Jie Yang, Ping Tai, Bo Zhou, Guoliang Xia*, Meijia Zhang*. Silencing of Mouse hepatic lanosterol 14alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by Short-term treatment of siRNA. Biological & Pharmaceutical Bulletin, 2008, June, 31(6):1182-1191. (IF: 1,574)
8.Xiuzhen Han#, Baoshan Xu#(Co-first author), Christopher S. Beevers, Yoshinobu Odaka, Long Chen, Lei Liu, Yan Luo, Hongyu Zhou, Wenxing Chen, Tao Shen, Shile Huang*. Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells. Carcinogenesis. 2012 Apr.; 33(4):868-875. (IF: 4.874)
9.Chen Long#, Baoshan Xu#(Co-first author), Lei Liu, Yan Luo, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Shile Huang*. Cadmium induction of reactive oxygen species activates mTOR pathway, leading to neuronal cell death. FREE RADICAL BIO. MED., 2011 Mar 1; 50(5):624-632. (IF: 5.784)
10.Long Chen#, Baoshan Xu#(Co-first author), Lei Liu, Yan Luo, Jun Yin, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Shile Huang*. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest., 2010 May 90(5): 762-773. (IF: 4.202)
11.Shaoxiao Wang, Baoshan Xu, Liangchun Liou, Qun Ren, Shile Huang , Yan Luo , Zhaojie Zhang, Stephan N Witt*. Alpha-Synuclein Disrupts Stress Signaling by Inhibiting Polo-like Kinase Cdc5/Plk2. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16119-24. (IF: 9.423)
12.Kobe C. Yuen, Baoshan Xu, Ian D. Krantz, Jennifer L. Gerton*. NIPBL controls RNA biogenesis to prevent activation of the stress kinase PKR. Cell Reports, 2016 Jan 5;14(1):93-102. (IF: 7.87)
13.Sujuan Chen#, Yijiao Xu#, Baoshan Xu#(Co-first author), Min Guo, Zhen Zhang, Lei Liu, Hongwei Ma, Zi Chen, Yan Luo, Shile Huang*, Long Chen*. Cadmium-elevated intracellular free Ca2+ activates MAPK and mTOR signaling by CaMKII phosphorylation leading to apoptosis of neuronal cells. J Neurochem. 2011 Dec; 119(5):1108-18. (IF: 3.842)
14.Chao Wang#, Baoshan Xu#(Co-first author), Bo Zhou, Cheng Zhang, Jie Yang, Hong Ouyang, Gang Ning, Meijia Zhang, Jianzhong Shen, Guoliang Xia*. Reducing CYP51 inhibits FSH-induced resumption of mouse oocyte meiosis in vitro. J Lipid Res., 2009 Nov. 50(11): 2164-2172. (IF: 4.368)
15.Hua Zhang#, Baoshan Xu#(Co-first author), Huirong Xie, Bo Zhou, Hong Ouyang, Gang Ning, Ge Li, Meijia Zhang*, Guoliang Xia*. Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial folliclepool in mouse fetal ovary. Molecular Reproduction and Development, 2009, May, 76(5): 514-521. (IF: 2.141)
16.Long Chen*, Baoshan Xu, Lei Liu, Chunxiao Liu, Yan Luo, Xin Chen, Mansoureh Barzegar, Jun Chung, Shile Huang*. Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion. Oncotarget. 2015 Mar 30;6(9):7136-50. (IF: 5.008)
17.Yoshinobu Odaka, Baoshan Xu, Yan Luo, Tao Shen, Chaowei Shang, Yang Wu, Hongyu Zhou, Shile Huang*. Dihydroartemisinin inhibits the mammalian target of rapamycin-mediated signaling pathways in tumor cells. Carcinogenesis. 2014 Jan; 35(1):192-200. (IF: 4.874)
18.Tania Bose, Kenneth K. Lee, Shuai Lu, Baoshan Xu, Bethany Harris, Brian Slaughter, Jay Unruh, Alexander Garrett, William McDowell, Andrew Box, Hua Li, Allison Peak, Sree Ramachandran, Chris Seidel, Jennifer L. Gerton*. Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells. PLoS Genetics. 2012 Jun; 8(6):e1002749. (IF: 6.661)
19.Xiufen Chen, Bo Zhou, Jun Yan, Baoshan Xu, Ping Tai, Junxia Li, Shiming Peng, Meijia Zhang*, Guoliang Xia*. Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced porcine cumulus–oocyte complexes meiotic resumption. Journal of Endocrinology, 2008, May, 197, 409-419. (IF: 4.498)
20.Xiaoming Song, Ping Tai, Jun Yan, Baoshan Xu, Xiufen Chen, Hong Ouyang, Meijia Zhang, Guoliang Xia*. Expression and regulation of lanosterol 14α-demethylase in mouse embryo and uterus during the peri-implantation period. Reproduction, Fertility and Development, 2008, Oct. 23, 20(8): 964–972. (IF: 2.135)
21.Gang Ning, Hong Ouyang, Songbo Wang, Xiufen Chen, Baoshan Xu, Jiange Yang, Hua Zhang, Meijia Zhang*, Guoliang Xia*. 3',5'-Cyclic Adenosine Monophosphate Response Element Binding Protein Up-Regulated Cytochrome P450 Lanosterol 14 α -Demethylase Expression Involved in Follicle-Stimulating Hormone-Induced Mouse Oocyte Maturation. Molecular Endocrinology, 2008, July, 22 (7): 1682-1694. (IF: 3.432)
22.Liu Lei, Yan Luo, Long Chen, Tao Shen, Baoshan Xu, Wenxing Chen, Hongyu Zhou, Xiuzhen Han, Shile Huang*. Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol. Chem., 2010 Dec. 3, 285(49), 38362-38373. (IF: 4.258)
23.Wenxing Chen, Yan Luo, Lei Liu, Hongyu Zhou, Baoshan Xu, Xiuzhen Han, Tao Shen, Zhijun Liu, Yin Lu, Shile Huang*. Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of rapamycin-mediated cyclin D1 expression and Rb Phosphorylation. Cancer Prev Res., 2010 Aug, 3(8): 1015-1025. (IF: 3.887)
24.Yong Joo Lee, Elodie Burlet, Shaoxiao Wang, Baoshan Xu, Shile Huang, Floyd J. Galiano, Stephan N. Witt*. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochem Biophys Res Commun. 2011 Oct 14; 414(1):205-8. (IF: 2.371)
25.Yan Luo, Hongyu Zhou, Lei Liu, Tao Shen, Wenxing Chen, Baoshan Xu, Xiuzhen Han, Fangfang Zhang, Rona S.Scott, J.Steve Alexander, Antoine Alam, Shile Huang*.The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway. Oncogene 2011 May 5, 30(18): 2098-2107. (IF: 7.932)
26.Guankun Mao, Junxia Li, Fenghua Bian, Yingying Han, Meng Guo, Baoshan Xu, Meijia Zhang, Guoliang Xia*. Gap junction-mediated cAMP movement between oocytes and somatic cells. Frontiers in Bioscience E5, January 1, 2013, 755-767. ?(IF: 2.484)
27.Lei Liu, Long Chen, Yan Luo, Wenxing Chen, Hongyu Zhou, Baoshan Xu, Xiuzhen Han, Tao Shen, Shile Huang*. Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway. PLOS ONE, 2010, May 11; 5(5):e10578. (IF: 3.057)
28.Hongyu Zhou, Tao Shen, Yan Luo, Lei Liu, Wenxing Chen, Baoshan Xu, Xiuzhen Han, Jia Pang, Chantal A. Rivera, Shile Huang*. The antitumor activity of the fungicide ciclopirox. Int. J Cancer, 2010 Nov 15;127(10):2467-2477. (IF: 5.531)
29.Xiaoming Song, Hong Ouyang, Ping Tai, Xiufen Chen, Baoshan Xu, Jun Yan, Guoliang Xia, Meijia Zhang*. Stage-specific Expression of Lanosterol 14 α -Demethylase in Mouse Oocytes in Relation to Fertilization and Embryo Development Competence. Asian-Aust. J. Anim. Sci., 2009, Mar., 22(3): 319-327.
30.Jiange Yang, Maoyong Fu, Songbo Wang, Xiufen Chen, Gang Ning, Baoshan Xu, Yuzhen Ma, Meijia Zhang, Guoliang Xia*. An antisense oligodeoxynucleotide to LH receptor attenuates FSH-induced oocyte maturation in mice. Asian-Aust. J. Anim. Sci., 2008 July, 21(7), 972-979.
31.Chao Wang#, Huirong Xie#, Xiaoming Song, Gang Ning, Jun Yan, Xiufen Chen, Baoshan Xu, Hong Ouyang, Guoliang Xia* ?Lanosterol 14α-demethylase expression in mice ovary and its participation in cumulus-enclosed oocyte spontaneous meiotic maturation in vitro, Theriogenology, 2006, Sep.15, 66(5): 1156-1164. ?(IF: 1.838)
[獲獎及學(xué)術(shù)榮譽(yù)]
1. ?美國Cornelia de Lange Syndrome Foundation 2014-2015年基礎(chǔ)科學(xué)獎
2. ?美國細(xì)胞生物學(xué)學(xué)會（ASCB）第50周年學(xué)術(shù)年會旅行獎 ? ?
3. ?美國科學(xué)促進(jìn)協(xié)會（AAAS）2011-2013年卓越科學(xué)項(xiàng)目獎
[社會兼職]
1. International Association for Dental Research（IADR）會員
2. American Society for Cell Biology（ASCB） 會員
3. The American Physiological Society （APS）會員
4. American Society for Investigative Pathology （ASIP）會員
5. American Association for the Advancement of Science （AAAS）會員
6. 多個SCI期刊特邀/長期審稿人，包括：International Journal of Cancer,，Toxicological Sciences,，Toxicology Letters，Acta Pharmacologica Sinica,，Asian Journal of Andrology,，Journal of cell death,，Theriogenology, Reproductive Biology and Endocrinolog, Molecular and Cellular Biochemistry，
International Journal of Molecular Sciences,，Chinese Journal of Cancer Research
[聯(lián)系方式]
地 址：廣州市中山二路74號,，中山大學(xué)（北校區(qū)）口腔醫(yī)學(xué)研究所（510080）
電 話：020-87330589
E-mail：[email protected] ?
許寶山
副研究員
博士生導(dǎo)師
導(dǎo)師簡介
