廣州市珠江科技新星
廣東特支計劃百千萬工程青年拔尖人才
廣東省“千百十人才工程”第八批培養(yǎng)對象
[學(xué)位/學(xué)歷]
醫(yī)學(xué)碩士 （中山大學(xué) 口腔臨床醫(yī)學(xué)）
醫(yī)學(xué)博士 （中山大學(xué) 口腔臨床醫(yī)學(xué)）
[學(xué)術(shù)簡歷]
2010-2011年 美國伊利諾伊大學(xué)芝加哥分校 訪問學(xué)者
2011-2013年 中山大學(xué)光華口腔醫(yī)學(xué)院 主治醫(yī)師/講師
2014年-至今 中山大學(xué)光華口腔醫(yī)學(xué)院 副主任醫(yī)師/副教授
[研究方向]
1.口腔癌分子發(fā)病機(jī)制
2.口腔癌精準(zhǔn)治療
[主持課題]
1.2016-2019年，F(xiàn)OSL1 ceRNA網(wǎng)絡(luò)調(diào)控舌鱗癌Tumor budding細(xì)胞侵襲轉(zhuǎn)移的分子機(jī)制，國家自然科學(xué)基金面上項目,，72萬
2.2014-2017年，PRC2-ncRNA“交互對話”調(diào)控舌鱗癌侵襲轉(zhuǎn)移的分子機(jī)制，廣州市珠江科技新星專項目，30萬
3.2013-2015年,，EZH2調(diào)控miRNAs促進(jìn)舌鱗癌侵襲轉(zhuǎn)移的分子機(jī)制，國家自然科學(xué)基金青年項目,，24萬
4.2012-2014年,，miR-204調(diào)控EMT促進(jìn)舌鱗癌侵襲轉(zhuǎn)移的分子機(jī)制，中央高?；究蒲袠I(yè)務(wù)費(fèi)專項資金,，15萬
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[發(fā)表論文]
1.Molecular Mechanisms of Chemoresistance in Oral Cancer. Chin J Dent Res. 2016;19(1):25-33.
2.Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early-stage tongue squamous cell carcinoma. J Oral Pathol Med. J Oral Pathol Med. 2015 ;44(4):266-72.
3.Beclin1 inhibits proliferation, migration and invasion in tongue squamous cell carcinoma cell lines. Oral Oncol. 2014;50(10):983-90.
4.Decrease of autophagy activity promotes malignant progression of tongue squamous cell carcinoma. J Oral Pathol Med. 2013 Aug;42(7):557-64.
5.Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma. Mol Carcinog. 2013;52(3):229-36.
6.Deregulation of Snai2 is associated with metastasis and poor prognosis in tongue squmous cell carcinoma. Int J Cancer. 2012;130(10):2249-58.
7.Tumor budding correlates with poor prognosis and epithelial- mesenchymal transition in tongue squamous cell carcinoma. J Oral Pathol Med. 2011;40(7):545-51.
8.Molecular characterization of the microRNA-138-Fos-like antigen 1 (FOSL1) regulatory module in squamous cell carcinoma. J Biol Chem. 2011;286(46):40104-9.
9.MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J. 2011;440(1):23-31.
10.Simultaneous maxillomandibular distraction osteogenesis in severe progressive hemifacial atrophy with two distractors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111(3):292-7.
11.The study of distraction osteogenesis with nitinol shape memory alloy controlled by infrared light. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(2):157-66.
12.Osteofascial Compartment Syndrome: A Rare and Severe Complication Involved in Free Fibula Osteocutaneous Flaps and a Kind of Its Treatments. J Craniofac Surg. 2011;22(3):1100-2.
13.MicroRNA-375 sensitizes tumour necrosis factor-alpha (TNF-α)-induced apoptosis in head and neck squamous cell carcinoma in vitro. Int J Oral Maxillofac Surg. 2013;42(8):949-55
14.p53 regulates the expression of human angiotensin II AT(2) receptor interacting protein (ATIP1) gene. Oncol Lett. 2011;2(5):919-922.
15.Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma. Hum Genet. 2011;129(2):189-97.
16.Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo. Biochem Pharmacol. 2011;82(1):17-23.
17.The expression and significance of MRP1, LRP, TOPOIIβ, and BCL2 in tongue squamous cell carcinoma. J Oral Pathol Med. 2012;41(2):141-8.
18.Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma. Oral Oncol. 2012;48(8):686-91.
19.Application of CAD/CAM-assisted technique with surgical treatment in reconstruction of the mandible. J Craniomaxillofac Surg. 2012;40(8):e432-7.
20.Immediate Reconstruction of Bilateral Mandible Defects: Management Based on Computer-Aided Design/Computer-Aided Manufacturing Rapid Prototyping Technology in Combination with Vascularized Fibular Osteomyocutaneous Flap. J Oral Maxillofac Surg. 2011;69(6):1792-7.
[參編教材與論著]
1.編委 全國衛(wèi)生專業(yè)技術(shù)資格考試習(xí)題集叢書《口腔頜面外科學(xué)習(xí)題精選》 人民衛(wèi)生出版社 2016,2015,2014
[獲獎及學(xué)術(shù)榮譽(yù)]
1. 專利 溫控鎳鈦形狀記憶合金牽引器 專利號ZL200720059381.6 中華人民共和國知識產(chǎn)權(quán)局 2008年
[社會兼職]
1.中華口腔醫(yī)學(xué)會口腔頜面外科專業(yè)委員會青年委員
2.中華口腔醫(yī)學(xué)會口腔生物醫(yī)學(xué)專業(yè)委員會青年委員
3.廣東省口腔醫(yī)學(xué)會口腔頜面外科專業(yè)委員會青年委員
[聯(lián)系方式]
地 址：廣州市陵園西路56號中山大學(xué)光華口腔醫(yī)學(xué)院?附屬口腔醫(yī)院（510055）
電 話：020-83862531
傳 真：020-87330446
E-mail：[email protected]
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