陳卓凡
教授
主任醫(yī)師
博士生導(dǎo)師
碩士生導(dǎo)師
導(dǎo)師簡(jiǎn)介
【學(xué)位 / 學(xué)歷】
博士研究生 / 口腔醫(yī)學(xué)博士
【學(xué)術(shù)簡(jiǎn)歷】
1988-1993 ?中山醫(yī)科大學(xué)口腔醫(yī)學(xué)專業(yè)獲學(xué)士學(xué)位
1998-2002 ?香港大學(xué)口腔醫(yī)學(xué)專業(yè)獲博士學(xué)位
【研究方向】
1.口腔種植相關(guān)軟硬組織再生修復(fù)
2.種植體周圍炎的機(jī)制與治療
3.數(shù)字化口腔種植治療的臨床應(yīng)用
【主持課題】
1.?2024-2027年：《基于靶向糖酵解調(diào)控多重免疫細(xì)胞平衡的2-脫氧葡萄糖 ?
遞送涂層構(gòu)建及其促進(jìn)炎癥種植體骨再結(jié)合的作用機(jī)制研究》，中國(guó)牙病防治基金會(huì)口腔種植科學(xué)研究專項(xiàng)基金，20萬(wàn)
2.?2020-2023年：《多功能微量營(yíng)養(yǎng)元素植入引導(dǎo)骨組織再生材料的基礎(chǔ)研究及臨床轉(zhuǎn)化》，廣東省人民政府高水平醫(yī)院建設(shè)登峰計(jì)劃，100萬(wàn)
3.?2019-2023年：《Zn-nHA/PLGA/FBHA復(fù)合材料通過(guò)調(diào)控Th17/Treg細(xì)胞平衡影響種植體周圍炎骨微環(huán)境促進(jìn)骨缺損修復(fù)的研究》，國(guó)家自然科學(xué)基金面上項(xiàng)目，55萬(wàn)
【發(fā)表論文】
1.Liu G#, Deng S#, Liu R, Liu Y, Liu Q, Wu S, Chen Z*, Liu R*. Precise multi-factor immediate implant placement decision models based on machine learning. Sci Rep. 2025 Feb 12;15(1):5143. (IF: 3.8)
2.Wu X#, Xu C#, Feng J#, Wu S, Liu R, Qiao W, Luo X, Chen S, Li Z*, Chen Z*. Fluorinated Porcine Bone-Derived Hydroxyapatite Promotes Vascularized Osteogenesis by Coordinating Human Bone Marrow Mesenchymal Stem Cell/Human Umbilical Vein Endothelial Cell Complexes. Bioengineering (Basel). 2024 Dec 18;11(12):1287. (IF: 3.8)
3.Shoucheng Chen#, Guangqi Gao#, Jiamin Shi#, Na Li#, Lv Xie, Yingye Zhang, Zhengjie Shan, Jiaxin Xie, Yin Xiao*, Zhuofan Chen*, Zetao Chen*. Unveiling the governing role of ‘emodeling triangle area’ in soft-hard tissue interface equilibrium for metal implants advancement. Materials Today Bio, Volume 28, ?2024, 101170. (IF: 8.7)
4.Liu X#, Deng S#, Li X#, Liu H, Li Z, Wu Y, Luo P, Zhong X, Huang R, Liu R, Wu X, Huang B, Chen Z*, Chen Z*, Chen S*. A Standardized Rat Model to Study Peri-implantitis of Transmucosal Osseointegrated Implants. Biomater Res. 2024 Jun 1;28:0021. (IF: 8.1)
5.Li C#, Su M#, Mai M#, Guo Z, Li Y, Chen S, Liu Q, Chen D, Wu X, Chen Z*, Chen Z*, Wu S*. Calcium enrichment activity initiates extracellular calcium influx-dependent inflammatory response of biologically-derived hydroxyapatite. Mater Today Bio. 2024 Sep 4;28:101231. (IF: 8.7)
6.Chen K#, Ha S#, Xu L#, Liu C, Liu Y, Wu X, Li Z, Wu S*, Yang B*, Chen Z*. Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation. J Transl Med. 2024 May 8;22(1):437. (IF: 6.1)
7.Xu X#, Feng J#, Lin T, Liu R, Chen Z*. miR-181a/MSC-Loaded Nano-Hydroxyapatite/Collagen Accelerated Bone Defect Repair in Rats by Targeting Ferroptosis Pathway. J Funct Biomater. 2024 Dec 20;15(12):385. (IF: 5.0)
8.Luo P#, Huang R#, Wu Y#, Liu X, Shan Z, Gong L, Deng S, Liu H, Fang J, Wu S, Wu X, Liu Q, Chen Z, Yeung KWK, Qiao W*, Chen S*, Chen Z*. Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation. Bioact Mater. 2023 May 17;28:95-111. (IF: 18.0)
9.Shoucheng Chen#, Jiamin Shi#, Guangqi Gao#, Lv Xie, Yingye Zhang, Zhengjie Shan, Zhuwei Huang, Xinchun Zhang*, Zhuofan Chen*, Zetao Chen*. Immunomodulation-based development engineering for advancing metal soft tissue implants, Smart Materials in Medicine, Volume 4, 2023, 562-577. (IF: 14.0)
10.Liu X#, Deng S#, Xie J#, Xu C, Huang Z, Huang B, Chen Z*, Chen S*. 2-DG Regulates Immune Imbalance on the Titanium Surface after Debridement. Int J Mol Sci. 2023 Jul 13;24(14):11431. (IF: 4.9)
11.Chen D#, Li Z#, Li Z, Sun Y, Liu Q, Yang J, Song J, Cai H, Feng Z, Chen Z*, Huang B*. Transcriptome analysis of human peri-implant soft tissue and periodontal gingiva: a paired design study. Clin Oral Investig. 2023 Jul;27(7):3937-3948. ?(IF: 3.1)
12.Li X#, Li C#, Su M#, Zhong X, Xing Y, Shan Z, Chen S, Liu X, Wu X, Liu Q, Li Y, Wu S*, Chen Z*. Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process. Sci Technol Adv Mater. 2023 Mar 13;24(1):2186690. (IF: 7.4)
13.Su M#, Li C#, Deng S#, Xu L, Shan Z, Xing Y, Li X, Li Y, Liu X, Zhong X, Chen K, Chen S, Liu Q, Wu X, Chen Z*, Wu S*, Chen Z*. Balance between the CMC/ACP Nanocomplex and Blood Assimilation Orchestrates Immunomodulation of the Biomineralized Collagen Matrix. ACS Appl Mater Interfaces. 2023 Dec 20;15(50):58166-58180. (IF: 9.5)
14.Sun Y, Yang J, Chen K, Li Z, Chen Z*, Huang B*. Clinical and radiographic results of crestal vs. subcrestal placement of implants in posterior areas: A split-mouth randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023 Oct;25(5):948-959. (IF: 3.7)
15.Wu S#, Shan Z#, Xie L#, Su M, Zeng P, Huang P, Zeng L, Sheng X, Li Z, Zeng G#, Chen Z#, Chen Z#. Mesopore Controls the Responses of Blood Clot-Immune Complex via Modulating Fibrin Network.?Advanced science. 2022 Jan; 9(3):e2103608. (IF: 15.1)
16.Liu Q, Sun Y, Chen D, Chen K, Huang B*, Chen Z*. Inhibitory effect of roflumilast on experimental periodontitis. Journal of periodontology. 2022 Mar; 93(3):423-434. ?(IF: 4.3)
17.Chen S#, Huang Z#, Visalakshan RM, Liu H, Bachhuka A, Wu Y, Dabare PRL, Luo P, Liu R, Gong Z, Xiao Y, Vasilev K*, Chen Z*, Chen Z*. Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance "epithelial barrier structure" formation via FN-ITG β1-FAK-mTOR signaling cascade. Biomaterials Research. 2022 Dec 26;26(1):88. ?(IF: 11.3)
18.Wu Y#, Chen SC#, Luo P#, Deng SD, Shan ZJ, Fang JH, Liu XC, Xie JX, Liu RH, Wu SY, Wu XY, Chen ZT, Yeung KW K, Liu Q*, Chen ZF*. Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite. Acta Biomater, 2022, Available online. (IF: 8.947)
19.Lin YX#,, Shi MR#,, Xiang DW, Zeng PS, Gong ZH, Liu H, Liu Q, Xia J, Chen ZF, Chen ZT*. Construction of an end-to-end regression neural network for the determination of a quantitative index sagittal root inclination. J Periodontol. 2022. doi: 10.1002/JPER.21-0492. Epub ahead of print. (IF: 6.993)
20.Qiao W, Wong KHM, Shen J, Wang W, Wu J, Li J, Lin Z, Chen Z, Matinlinna JP, Zheng Y, Wu S, Liu X, Lai KP, Chen ZF*, Lam YW*, Cheung KMC, Yeung KW K*. TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration, Nat Commun, 2021, 12(1):2885. (IF:14.919)
21.Chen KD#, Li ZP#, Liu X, Liu Q, Chen ZT, Sun Y, Chen ZF*, Huang BX*, Immediate Implant Placement with Buccal Bone Augmentation in the Anterior Maxilla with Thin Buccal Plate: A One-Year Follow-Up Case Series, J Prosthodont. 2021;30(6):473-480. (IF:2.752)
22.Chen DY, Wu XY, Liu Q, Cai HX, Huang BX*, Chen ZF*, Memory B Cell as an Indicator of Peri-implantitis Status: A Pilot Study. Int J Oral Maxillofac Implants, 2021, 36(1):86-93. (IF:2.804)
23.Guo YL#, Mi JM#, Ye C#, Ao Y, Shi MR, Shan ZJ, Li BZ, Chen ZT*, Chen ZF, Vasilev Krasimir, Xiao Y, A practical guide to promote informatics-driven efficient biotopographic material development, Bioact Mater, 2021, Epub ahead of print. (IF: 18.0)
24.Liu QF#, Sun Y#, Chen DY, Chen KD, Huang BX*, Chen ZF, Inhibitory effect of roflumilast on experimental periodontitis. J Periodontol, 2021, Epub ahead of print. (IF: 6.993)
25.Liu YX#, Liu CW#, Huang RX, Chen KD, Huang BX, Liu Q, Chen ZF*, Li ZP*, Effects of fluorinated porcine hydroxyapatite on lateral ridge augmentation: an experimental study in the canine mandible, Am J Transl Res, 2020, 12, 2473-2487. (IF: 4.060)
26.Fang JH#, Liu RH#, Chen SC, Liu Q, Cai HX, Lin YX, Chen ZT*, Chen ZF*, Tuning the immune reaction to manipulate the cell-mediated degradation of a collagen barrier membrane, Acta Biomater, 2020, 109, 95-108. (IF: 8.947)
27.Huang RX#, Liu YX#, Huang BX, Zhang CB, Chen ZF*, Li ZP*, Improved scanning accuracy with newly designed scan bodies: An in vitro study comparing digital versus conventional impression techniques for complete-arch implant rehabilitation, Clinic Oral Imp Res, 2020, 31(7):625-633. (IF: 5.977)
28.Liu RH#, Chen SC#, Huang PN, Liu GQ, Luo P, Li ZP, Xiao Y, Chen ZF*, Chen ZT*, Immunomodulation-based strategy for improving soft tissue and metal implant integration and its implications in the development of metal soft tissue materials, Adv Func Mater, 2020. (accepted, DOI:10.1002/adfm.201910672) (IF: 18.808)
29.Han AF#, Ding H, Tsoi J K H, Imazato S, Matinlinna J P, Chen ZF*, Prolonged uv-c irradiation is a double-edged sword on the zirconia surface, ACS omega, 2020, 5, 10, 5126-5133. (IF: 3.512)
30.Liu GQ#, Wang XS#, Zhou X#, Zhang LJ, Mi JM, Shan ZJ, Huang BX*, Chen ZF*, Chen ZT*, Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: A strategy to resolve the controversies about cobalt use for orthopedic applications, Theranostics, 2020, 10, 3, 1074. (IF: 11.556)
31.Pan Y, Tam JM, Tsoi JK, Lam WY, Huang R, Chen ZF*, Pow EH*. Evaluation of laboratory scanner accuracy by a novel calibration block for complete-arch implant rehabilitation. J Dent. 2020, 102:103476. (IF: 4.379)
【參編教材與論著】
1.?2023年 參編《口腔種植學(xué)》研究生教材 人民衛(wèi)生出版社?978-7-117-34857-7
2.?2010年 主編《口腔種植治療的基礎(chǔ)研究與臨床應(yīng)用》 人民軍醫(yī)出版社?978-7-5091-3639-3
3.?2014年 參編《口腔種植學(xué)》北京大學(xué)口腔醫(yī)學(xué)八年制教材 北京大學(xué)醫(yī)學(xué)出版社 978-7-5659-0758-6
4.?2018年 副主編《口腔種植學(xué)詞典》 人民衛(wèi)生出版社?978-7-117-30565-5
【社會(huì)兼職】
1.?中華口腔醫(yī)學(xué)會(huì)口腔種植專委會(huì)副主任委員
2.?廣東省口腔醫(yī)學(xué)會(huì)口腔種植專委會(huì)主任委員
3.?廣東省精準(zhǔn)醫(yī)學(xué)應(yīng)用學(xué)會(huì)口腔修復(fù)種植分會(huì)主任委員
4.?廣東省口腔醫(yī)學(xué)會(huì)常務(wù)理事
5.?香港大學(xué)牙醫(yī)學(xué)院榮譽(yù)教授（Honorary Professor）
6.?香港口腔種植學(xué)會(huì)副會(huì)長(zhǎng)
7.?中華口腔醫(yī)學(xué)研究雜志（電子版）編委
8.?中華口腔種植學(xué)雜志副主編
9.?Implant Dentistry Editor (Council/Section)
【聯(lián)系方式】
地址：廣東省廣州市越秀區(qū)陵園西路56號(hào)
電話：020-83862537
